PernaVita flex tablets

Scientifically proven:

1. MSM and glucosamine – significantly reduce joint pain and swelling in osteoarthritis. A total of 118 patients( 40-70 years) with mild to moderate osteoarthritis were included in the study. Combination treatment resulted in a more significant decrease in the mean pain index (1.7 ± 0.47 to 0.36 ± 0.33) 12 weeks after administration.  The mean swelling index significantly decreased with combination therapy (1.43 ± 0.63 to 0.14 ± 0.35) after 12 weeks.¹
2. Green-lipped mussel – regulation of anti-inflammatory cytokines and provision of nutritional factors for connective tissue regeneration (chondroitin sulfate, collagen, glycogen).²
3. Condoritin – sulfate – therapeutic effect on osteoarthritis through 3 mechanisms: 1) anti-inflammatory action without the side effects that occur in other NSAIDs, 2) metabolic effect on the synthesis of hyaluronate and cartilage proteoglycans, 3) inhibition of proteolytic activities (collagenase, elastase, proteoglycans).³
4. Hyaluronic acid – helps with knee pain, relieves symptoms of osteoarthritis, reduces stiffness and improves physical function of the joints. After 8 weeks (47 patients) the pain index decreased (1.6 ± 1.61 vs 3.3 ± 2.16, P = .01) and physical function improved (4.5 ± 4.25 vs 7.9 ± 6.30, P = .03).⁴
5. Calcium fructoburate – has an anti-inflammatory effect and inhibits superoxide within the cell, the production of IL-1β, IL-6 and nitric oxide. It also increases the production of TNF-α. A dose of 1-7 mg of calcium fructoborate (0.025–0.175 mg of boron)/kg per day has been shown to show good anti-inflammatory effects and have minor side effects.⁵
6. Vitamin D3 – has an anti-inflammatory effect and affects bone formation and resorption. The active form of vitamin D, 1.25 (OH) 2D3, has regulatory autocrine and paracrine properties at the site of inflammation and is recognized as an immunosuppressant that enhances the pathogenesis of autoimmune diseases regulated by Th1 lymphocytes.⁶
7. Manganese- when taken in combination with other nutrients, manganese supports bone mineral density, and studies confirm that manganese in combination with glucosamine and chondroitin reduces the pain caused by osteoarthritis. Glycosyltranferases and xylosyltransferases are important for proteoglycan synthesis and thus bone formation and are sensitive to manganese intake.⁷

Literature:

¹Usha, P.R., Naidu, M.U.R. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis.  Drug Investig.24, 353–363 (2004)./²New Research and a Clinical Report on the Use of Perna Canaliculus in the Management of Arthritis by Roger V. Kendall, PhD., Vice President of Research and Development, FoodScience Corporation, John W. Lawson, PhD., Department of Microbioogy and Molecular Medicine, Clemson University ˛& Lloyd A. Hurley, MD., Corrales, New Mexico./³Ronca, F., Palmieri, L., Panicucci, P., & Ronca, G. (1998). Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis and cartilage, 6 Suppl A, 14–21. https://doi.org/10.1016/s1063-4584(98)80006-/⁴Wang, S. J., Wang, Y. H., & Huang, L. C. (2021). The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial. Medicine, 100(5), e24252./⁵Scorei, R.I., Rotaru, P. Calcium Fructoborate—Potential Anti-inflammatory Agent. Biol Trace Elem Res 143, 1223–1238 (2011)./⁶Cantorna M. T. (2010). Mechanisms underlying the effect of vitamin D on the immune system. The Proceedings of the Nutrition Society, 69(3), 286–289./⁷European Food Safety Authority. Scientific Opinion on the substantiation of health claims related to manganese and protection of DNA, proteins and lipids from oxidative damage (ID 309), maintenance of bone (ID 310), energy-yielding metabolism (ID 311), and cognitive function (ID 340) pursuant to Article 13(1) of Regulation (EC) No 1924/20061. EFSA Journal 2009; 7(9):1217